Wednesday, May 23, 2018 at 3:30pm to 4:30pm
Zilkha Neurogenetic Institute (ZNI), 112, Herklotz Seminar Room
1501 San Pablo, Los Angeles, CA 90033
Cerebral small vessel disease (SVD) encompasses a wide range of imaging features which are highly relevant clinically, being implicated in a fifth of strokes and around 45% of dementias. The diversity of symptoms poses particular challenges for research in humans and in preclinical models, which often fail to reflect key aspects of the clinical pathologies. MRI is a valuable tool in the diagnosis of SVD which is associated with a variety of structural imaging features, however these can be nonspecific and are also common in healthy ageing. Consequently a variety of advanced neuroimaging techniques have been applied to study different aspects of the disease, revealing evidence of impaired cerebrovascular reactivity (CVR) and blood brain barrier (BBB) leakage, though further research is needed to develop understanding of the underpinning mechanisms and role of such changes in SVD.