BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
X-WR-CALNAME:ZNI Seminar Series: "How Metal Ions in the Brain Tip the Toxic
  Balance of the Killer Prion Protein"
X-WR-TIMEZONE:Pacific Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260818T115826Z
UID:tag:localist.com\,2008:EventInstance_2974224
DTSTART:20170920T190000Z
DTEND:20170920T200000Z
DESCRIPTION:A prion is a misfolded form of the cellular prion protein\, PrP
 C.  Although the role of PrP in neurodegeneration was established over 30 
 years ago\, there is little understanding of the protein’s normal functi
 on\, and how misfolding leads to profound disease.  Recent work shows that
  PrPC coordinates Cu2+ and Zn2+ cofactors\, and regulates the distribution
  of these essential metal ions in the brain.  Moreover\, these metals stab
 ilize a previously unseen fold in PrPC\, the observation of which provides
  new insight into the mechanism of prion disease\, and perhaps other neuro
 degenerative diseases.  I will provide a brief background on prion disease
 s and discuss physiology and magnetic resonance experiments that reveal a 
 new PrPC fold feature promoted by metal ions.
GEO:34.062459;-118.203452
LOCATION:Zilkha Neurogenetic Institute (ZNI)\, Herklotz Seminar Room\, ZNI 
 112
SUMMARY:ZNI Seminar Series: "How Metal Ions in the Brain Tip the Toxic Bala
 nce of the Killer Prion Protein"
URL;VALUE=URI:https://calendar.usc.edu/event/zni_seminar_series_how_metal_i
 ons_in_the_brain_tip_the_toxic_balance_of_the_killer_prion_protein
CATEGORIES:Lecture / Talk / Workshop
END:VEVENT
END:VCALENDAR