In this talk, Dr. Hell will show that the beta 2 adrenergic receptor forms signaling complexes with AMPARs and Cav1.2, which also contain Gs, adenylyl cyclase, and PKA. Regulation of AMPAR and Cav1.2  phosphorylation and activity by beta2 adrenergic - cAMP signaling requires the formation of these complexes and is spatially highly restricted. Both complexes as well as phosphporylation of GluA1 and Cav1.2 by PKA upon beta2 adrenergic stimulation are required for LTP induced by a prolonged theta tetanus.