ZNI Seminar Series : "Beta 2 Adrenergic Receptor Signaling Complexes with AMPARs and the Calcium Channel Cav1.2”
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1501 San Pablo, Los Angeles, CA 90033
In this talk, Dr. Hell will show that the beta 2 adrenergic receptor forms signaling complexes with AMPARs and Cav1.2, which also contain Gs, adenylyl cyclase, and PKA. Regulation of AMPAR and Cav1.2 phosphorylation and activity by beta2 adrenergic - cAMP signaling requires the formation of these complexes and is spatially highly restricted. Both complexes as well as phosphporylation of GluA1 and Cav1.2 by PKA upon beta2 adrenergic stimulation are required for LTP induced by a prolonged theta tetanus.
This program is open to all eligible individuals. USC operates all of its programs and activities consistent with the university’s Notice of Non-Discrimination. Eligibility is not determined based on race, sex, ethnicity, sexual orientation or any other prohibited factor.
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