Lightly stroking the lips or gently poking some skin regions can evoke mechanical itch in healthy human subjects. Sensitization of mechanical itch and persistent spontaneous itch are intractable symptoms in chronic itch patients. However, the underlying neural circuits are not well defined. We have identified the neuronal pathway, from the skin to the spinal cord, responsible for transmitting mechanical itch, opening the pathway for treating patients with chronic itch.

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