My work focuses on the molecular and cellular basis of neural circuit wiring and rewiring, using the mouse retina as a model, with the goal to reconstruct neural circuits and restore physiological functions subject to neurological diseases and neuronal injuries. My previous work addressed how defined subtypes of neurons wire up during retinal development (Duan et al Cell, 2014; Neuron, 2018), and how defined subtypes of retinal ganglion cells mediate axon regeneration in response to injury (Duan et al, Neuron, 2015). The study provided direct evidence for a long-hypothesized “cadherin code” that instructs the specificity of the circuit assembly.  In this seminar, I will discuss how we utilize such connectivity code to under visual circuits’ assembly, and how we build the next generation of circuit tracing and sequencing tools to understand fundamental mechanisms of circuit assembly and identify new avenues for neuronal regeneration and stem cell-based neuronal repair.

https://usc.zoom.us/j/92727703646?pwd=b21nQk5BZVlVck1XcndSYnlNWWk2Zz09

Meeting ID: 927 2770 3646

Password: 271140

Telephone:      +1 669 900 6833 or +1 346 248 7799