Wednesday, October 3, 2018 at 12:00pm to 1:00pm
Zilkha Neurogenetic Institute (ZNI), Herklotz Seminar Room 112
1501 San Pablo, Los Angeles, CA 90033
What is the underlying neural mechanisms that contribute to the trial-by-trial fluctuations in sensory response and decision making? The locus coeruleus-norepinephrine (LC-NE) system has long been thought to have a critical role in regulating multiple aspects of cognitive behavior, including perception, attentiveness and decision making. To understand how this neuromodulatory system is involved in regulating S1 sensory responses and tactile perception, we made simultaneous extracellular recordings from LC-NE neurons and intracellular (whole-cell) recordings from S1 neurons during the detection task. We found that LC spiking activity correlated with membrane potential depolarization of S1 neurons as well as behavioral outcomes. Our results suggest that LC-NE inputs modulate sensory information processing to facilitate sensory perception.
Hongdian Yang, PhD
Department of Molecular, Cell and Systems Biology
University of California, Riverside