Zilkha Seminar Series - Yi Zuo PhD: “Experience-Dependent Synapse Reorganization in the Living Brain”

Wednesday, May 29, 2019 at 12:00pm to 1:00pm

This is a past event.

Zilkha Neurogenetic Institute (ZNI), 112
1501 San Pablo, Los Angeles, CA 90033

One fundamental question in neuroscience is how the brain processes and stores information. As the information-processing elements in the brain, neurons communicate via specialized connections called synapses. The majority of excitatory synapses reside at dendritic spines, which serve as a good proxy for synaptic connectivity. Using transcranial two-photon microscopy to visualize fluorescently-labeled neurons in transgenic mice, our recent studies followed the dynamics of spines on apical dendrites of L5 pyramidal neurons in the living brain. In this talk, I will discuss our findings on how experience (both positive and negative) affects cortical circuits and synapse plasticity.

Event Type

Lecture / Talk / Workshop


Students, Alumni, Faculty/Staff


Health Sciences Campus

Keck School of Medicine
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