Thursday, October 14 at 1:00pm to 2:00pm
Broad CIRM Center (BCC), BCC 101 (maximum 50 people)
1425 San Pablo Street, Los Angeles, CA 90033
Note: The seminar will be held in BCC 101, with a maximum room occupancy of 50 attendees. For an overflow Zoom link, please email email@example.com.
Sequential segmentation of embryos creates modular body plans among diverse metazoan phyla, utilizing molecularly divergent clocks and morphogen gradients. While clock components and gradients were identified in vertebrates, how they jointly control somite segmentation remained unknown. Using real-time reporters, temporal perturbations, quantitative analysis, and computational modeling, we showed that the clock functions upstream of ERK gradient, which in turn enables neighboring cells to establish a boundary between them in zebrafish. We also found that pairing of two segmentation clock genes provides robustness in somite segmentation.
Host: T32 Program