Wednesday, December 5, 2018 at 12:00pm
Broad CIRM Center (BCC), First Floor Seminar Room
1425 San Pablo Street, Los Angeles, CA 90033
A quintessential challenge of regenerative medicine is that human pluripotent stem cell (hPSC) differentiation typically yields impure cell populations that are poorly suited for therapeutic applications. To tackle this challenge, we have delineated a roadmap that describes how hPSCs develop into over 20 different human cell-types within ~1 week of differentiation, including endodermal, mesodermal and ectoderm cell- types. This roadmap enables the rapid and efficient generation of human bone, heart and liver progenitors from hPSCs, each of which can engraft mice and regenerate their respective human tissue in vivo.
Host: Justin Ichida