Monday, June 24 at 11:00am to 12:00pm
Broad CIRM Center (BCC), First Floor Seminar Room
1425 San Pablo Street, Los Angeles, CA 90033
The adult intestinal epithelium, serving critical roles in nutrient absorption and host-microbe immune homeostasis, completely sheds and renews every 3-7 days, making it one of the fastest regenerating tissues in the body. This incredible turnover is driven by the rapid proliferation and differentiation of a specialized population of tissue-resident stem cells located at the base of the adult intestinal crypt, the fundamental organizational unit of intestinal epithelium. However, fetal intestinal epithelium does not have crypts, making the developmental origin of these adult stem cells a mystery. In this presentation, I will show recent data from my research group on the fetal origin of these adult stem cells. Strikingly the specification of these stem cells arises from morphogenesis of the small intestine during early postnatal life. These tissue-level structural rearrangements bring cells from distant parts of the intestinal villi to specific regions that will later comprise the adult stem cell niche. We believe similar forces, including the recapitulation of fetal stem cell programs, are at play in the repair and regeneration of adult intestinal tissue after injury. The developmental plasticity of intestinal epithelium has important implications for regenerative medicine in the treatment of many gastrointestinal diseases. .
Host: Tracy Grikscheit, MD & Cambrian Liu, PhD