Tuesday, May 28, 2019 at 11:00am to 12:00pm
Broad CIRM Center (BCC), First Floor Seminar Room
1425 San Pablo Street, Los Angeles, CA 90033
Live webcast at keckmedia.usc.edu/stem-cell-seminar
How cell diversity arises from progenitors and stem cells is an important scientific question across organ systems. With the broad recognition that disease frequently arises as cell identities form during development, it is a significant challenge to provide insights into diversity-generating mechanisms and models for perturbations resulting in disease. I will describe my recent efforts to delineate progenitor differentiation and lineage forming programs in the human and mouse kidney, using single-cell omics and lineage-tracing approaches, and discuss current opportunities for linking progenitors with their functional adult progeny and abnormal differentiation to kidney disease.