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We use human pluripotent stem cells to build advanced 2D and 3D models to study the development and disease of the neuromuscular system. We have recently pioneered the generation of a 3D neuromuscular organoid (NMO) model where spinal cord neurons and skeletal muscles self-organize to generate functional neuromuscular junctions. This model opens up new opportunities to study the mechanisms of human neuromuscular diseases like spinal muscular atrophy and amyotrophic lateral sclerosis.

Host: Justin Ichida

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