Tuesday, January 30, 2018 at 11:00am to 12:00pm
Broad CIRM Center (BCC), First Floor Seminar Room
1425 San Pablo Street, Los Angeles, CA 90033
Development of the face and cranium of vertebrates is tightly regulated by a large number of genes, and disruption in this process can lead to craniofacial birth defects. We study genetic regulation of craniofacial development using mice as a model system. In particular, we have investigated the role of genes encoding LIM homeodomain transcription factors in development of the palate and the calvaria. Our data indicate that Lhx6 and Lhx8 play an essential role to normal growth of the palate by repressing a cell cycle inhibitor gene. In addition, Lmx1b regulates patterning of the calvaria into bone and soft tissue joints by region-specific inhibition of bone formation.
Host: Gage Crump
Live webcast at keckmedia.usc.edu/stem-cell-seminar