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Zebrafish display a high regenerative capacity including of their adult organs. We use this vertebrate model to investigate adult heart regeneration. While most studies to date have focused on cardiomyocyte proliferation after injury, we are taking a more global view of the regenerative program including investigating the role of other cell types in the heart, and of processes such as inflammation and revascularization. In addition, we use the medaka, another fish model amenable to genetic studies, that surprisingly cannot regenerate its heart. Comparative studies of the zebrafish and medaka hearts illustrate the critical role of inflammation in the regeneration process.

Host: Francesca Mariani

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