USC Stem Cell Seminar: Ben Simons, Wellcome Trust—"Theories of stem cell renewal"

Tuesday, May 4 at 11:00am to 12:00pm

This is a past event.

To ensure Zoom meeting security, all participants are required to register once for this series.  Once you register, you will be provided with a Zoom link that is valid for all seminars in the series.  For your convenience, please add the link to your Outlook calendar. To register, please visit: Seminar Registration. Questions? please contact: stemcell@usc.edu.

Abstract: To replenish cells lost through exhaustion or damage, tissue stem cells must achieve a perfect balance between renewal and differentiation. To study the factors that control fate asymmetry, emphasis has been placed on mechanisms in which stem cell competence relies on signals from a discrete anatomical niche. However, in many tissues, stem cell maintenance takes place in a "facultative" niche, where stem cells disperse among their differentiating progenies. Using mouse spermatogenesis as a model, we show that stem cell density regulation relies on a feedback mechanism, reminiscent of "quorum sensing", in which stem cells transition reversibly between states biased for renewal and primed for differentiation. Using a modelling-based approach, we show that this mechanism provides predictive insights into stem cell dynamics during steady-state, as well as under perturbed and transplantation conditions. We discuss the implications of these findings for stem cell flexibility, plasticity and density regulation in other epithelial tissues.

Hosts: Rong Lu and Michael Bonaguidi

Event Type

Lecture / Talk / Workshop

Campus

Other Location

Tags

stemcell

Department
Stem Cell at USC
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