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"Investigating and Targeting Neurodegeneration with In Vitro Models of the Human Brain"

Many individuals possess a genetic susceptibility to neurodegenerative diseases like Alzheimer's disease (AD). However, identifying the genetic factors that cause AD, understanding their cellular and molecular mechanisms, and developing effective treatments remain significant challenges. These challenges are reflected in the growing number of patients and the lack of effective therapies for AD and related dementias. To address this gap, my lab engineers 3D models of human brain tissue from stem cells and applies this technology to predict, prevent, and treat AD. I will discuss our efforts to advance the physiological complexity of human brain models, the application of this technology to establish the cellular and molecular pathways underlying AD risk factors, and subsequently targeting and modulating these pathways as potential therapeutic strategies.