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"From Single Cells to Tissues: Gut Endoderm Development in Mice"

The gut endoderm is the embryonic precursor of the respiratory and digestive tracts and their associated organs, including the lungs, liver and pancreas. By employing a combination of approaches including quantitative imaging, single-cell genomics and perturbations, we are determining mechanisms driving gut endoderm development in vivo in mouse embryos, and in vitro in mouse and human stem cell-based models. I will discuss ongoing studies determining the origin, fate and formation of the gut endoderm, and integrating single-cell resolution multiplexed imaging of gene expression to spatially annotate single-cell genomic data to map cell identities in 3D.