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CATEGORIES:Lecture / Talk / Workshop
DESCRIPTION:Dr. Syed Ahmed\, Associate Director\, Medicinal Chemistry Core\
 , to present:\n\n"Design\, Optimize\, Deliver: Medicinal Chemistry from Hit
  to Lead"\n \n\nABSTRACT: Drug discovery is increasingly driven by the inte
 gration of ligand and structure-based design to efficiently identify and ad
 vance small-molecule therapeutics from initial hits to optimized leads. Fol
 lowing hit identification\, candidates undergo iterative cycles of molecula
 r design\, chemical synthesis\, and biological evaluation to enhance potenc
 y\, target selectivity\, and developability. Medicinal chemistry efforts fo
 cus on refining target engagement while optimizing physicochemical properti
 es\, pharmacokinetics\, and safety profiles. Computational and AI-enabled t
 ools support these efforts by guiding structure–property relationships\, pr
 edicting ADME/toxicity liabilities\, and informing rational decision-making
 .\nIntegrating classical design principles with robust lead optimization st
 rategies provides a powerful framework for generating high-quality developm
 ent candidates\, enhancing efficiency\, reducing attrition\, and enabling t
 he delivery of optimized leads with strong clinical potential.\nThis talk w
 ill highlight emerging workflows\, showcase recent NIH\, and externally fun
 ded medicinal chemistry projects\, and discuss how these integrated approac
 hes are shaping the future of precision drug discovery across diverse thera
 peutic areas.
DTEND:20260210T210000Z
DTSTAMP:20260309T210215Z
DTSTART:20260210T200000Z
GEO:34.060373;-118.205954
LOCATION:USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences\
 , PSC 104
SEQUENCE:0
SUMMARY:USC Mann Integrated Core Services Seminar Series
UID:tag:localist.com\,2008:EventInstance_51960036358215
URL:https://calendar.usc.edu/event/usc-mann-integrated-core-services-semina
 r-series
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