Dr. Landi is an M.D., Ph.D. with training in clinical oncology and molecular epidemiology. She is Senior Advisor for Genomic Epidemiology, Trans-Divisional Research Program, and Senior Investigator, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH. She focuses her research on the genetic and environmental determinants of lung cancer and melanoma, and on the genomic characterization of these tumors. She is PI of both EAGLE and Sherlock-Lung, two landmark studies of lung cancer in smokers and never smokers, respectively, which identified subtypes with distinct genomic features, mutational signatures, and evolutionary trajectories. In this talk, Dr. Landi will briefly describe the Sherlock-Lung study, and report on the mutational signatures identified in lung cancer from never smokers and their implications for understanding cancer etiology. Dr. Landi will then describe how even a mutational signature of a previously unknown mutational process was key to identify a new mechanism shaping lung cancer tumor evolution.