The USC Mann Department of Pharmacology and Pharmaceutical Sciences will host a seminar, "Targets and Functions of tRNA Modification Enzymes," presented by Dr. Dragony Fu, associate professor of biology at University of Rochester, at 12 noon on Friday, March 31 in PSC 104. 

Abstract: Transfer RNAs (tRNAs) are subject to numerous chemical modifications catalyzed by tRNA modification enzymes. Genetic variants in tRNA modification enzymes have been linked to devastating neurodevelopmental and neurological disorders. However, the molecular mechanisms underpinning these pathologies are unknown. Why is it that perturbations to many different tRNA modification enzymes seem to affect the brain more so than other organs? To resolve this question, our lab seeks to elucidate the molecular and cellular roles of tRNA modification enzymes in human health and disease. We use biochemistry to identify targets of tRNA modification enzymes combined with mouse models to decipher the role of tRNA modification in biological processes. These studies provide insight into how tRNA modifications impact neurodevelopment and uncover potential therapeutic strategies for individuals with neurological disorders caused by tRNA modification deficiency.

Refreshments will be served. 

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