3641 Watt Way, Los Angeles, CA 90089

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Research Topics

The lab is broadly interested in synapses, the specialized cellular junctions essential for rapid communication between neurons. These synaptic junctions physically and functionally connect individual neurons into continuous neural circuits that give rise to behavior and cognition. Currently, research in the lab is focused on the regulation of the structure and function of synapses, in particular molecular mechanisms underlying synaptic plasticity, a cellular model for learning and memory. We are also interested in mechanisms and function of the interaction between glutamatergic synaptic transmission and neuromodulation at both synaptic and systems levels. The lab extensively employs techniques in electrophysiology, molecular biology and in vivo manipulation of neuronal gene expression, and is equipped with state-of-the-art mouse genetic tools to facilitate scientific discoveries. These genetic tools allow one to eliminate glutamatergic synaptic input onto single neurons or specific brain regions.

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