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Linda Buck’s laboratory studies the molecular mechanisms and neural circuits that underlie the sense of smell and instinctive odor responses. They are interested in how the olfactory system detects myriad environmental chemicals and how the brain translates those chemicals into diverse odor perceptions, hormonal alterations, and instinctive behaviors. Illumination of the neural circuits underpinning these effects may provide clues to those affected in certain human disorders, particularly those involving stress, fear, and appetite.