Mindfulness-based interventions (MBIs) have long shown evidence of medium-sized effects for stress, chronic pain, and anxiety. Dr. King's research group and others have shown that MBIs can lead to enduring alterations in large-scale neural networks. This talk will explore specific adaptations of MBIs for depression and trauma / PTSD, potential neural mechanisms and treatment targets underlying their effects, and possible shared and unique pathways for MBIs in the treatment of depression and PTSD.