Friday, November 2, 2018 at 12:00pm to 1:00pm
Irani Hall (RRI), 101
1050 Childs Way, Los Angeles, CA 90089
"Single Neuron Transcriptomics to decipher Structure, Function, Connectivity for Taste pathways"
Abstract: Mammalian taste buds are innervated by neurons whose cell bodies reside in cranial sensory ganglia. Our understanding of the functions of these neurons have been hindered by a lack of knowledge of their heterogeneity and markers to distinguish them. Using single cell RNA sequencing of taste ganglion neurons and unbiased transcriptome analyses, we have corrected this shortfall. We have identified clear molecular classes of gustatory neurons, each with its own complement of transcription factors and neurotransmitter response profiles.We are now in the process of assessing the functional characerisitics of these classes of neurons and what their roles are in delivering sensory signals to the brain.