BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
X-WR-CALNAME: Molecular and Computational Biology Seminar: Allison J. Shult
 z\, PhD  (Natural History Museum of Los Angeles County\, Ornithology Depar
 tment)
X-WR-TIMEZONE:Pacific Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260714T012213Z
UID:tag:localist.com\,2008:EventInstance_4373339
DTSTART:20190301T200000Z
DTEND:20190301T210000Z
DESCRIPTION:“Evolution across timescales: comparative and population geno
 mics studies of host-pathogen co-evolution in birds”\n\nAbstract: Infect
 ious disease produces some of the strongest selective forces on natural po
 pulations across the tree of life. The signatures of pathogen-mediated evo
 lution on host genomes have been described for several traditional model o
 rganisms\, but few studies of more diverse organisms have detected such si
 gnatures beyond candidate immune loci. Here\, I combine population and com
 parative genomics to study the dynamics of pathogen-mediated selection at 
 across evolutionary timescales in birds. First\, I use alignments of 39 bi
 rd genomes to estimate parameters related to positive selection for 11\,00
 0 genes conserved across birds. I use functional pathway analyses\, transc
 riptome data\, and comparisons with mammals to show that pathogens\, parti
 cular viruses\, consistently target the same genes across divergent clades
 \, and that these genes are hotspots of host-pathogen conflict over deep e
 volutionary time. Second\, I use whole genome resequencing data to estimat
 e parameters of selection at the population level across birds\, and inves
 tigate if the same genes observed under selection at deep evolutionary tim
 escales are under selection at shallow evolutionary timescales. Finally\, 
 I use genomes of a songbird collected across time and space to understand 
 the demographic impacts of two anthropogenic disturbances\, an introductio
 n event and a novel pathogen. I find that the demographic history had the 
 largest genomic impact\, and that pathogen-mediated selection likely occur
 red at many different regions of the genome.
GEO:34.022631;-118.290533
LOCATION:Irani Hall (RRI)\, 101
SUMMARY: Molecular and Computational Biology Seminar: Allison J. Shultz\, P
 hD  (Natural History Museum of Los Angeles County\, Ornithology Department
 )
URL;VALUE=URI:https://calendar.usc.edu/event/molecular_and_computational_bi
 ology_seminar_allison_j_shultz_phd_natural_history_museum_of_los_angeles_c
 ounty_ornithology_department
CATEGORIES:Lecture / Talk / Workshop
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