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CATEGORIES:Lecture / Talk / Workshop
DESCRIPTION:Title: “Polymerase Theta: A Cancer Drug target with Reverse Tra
 nscriptase Activity” \n\n \n\nAbstract: DNA polymerase theta (Polq) is a va
 lidated anti-cancer drug target that is synthetic lethal with homologous re
 combination (HR) factors and other DNA repair proteins\, and confers cellul
 ar resistance to various genotoxic cancer therapies. POLQ is a unique gene 
 in higher eukaryotic cells since it is the only known helicase-polymerase f
 usion protein. Mechanisms of Polq polymerase and helicase activities in DNA
  repair will be discussed\, as well as it’s newly discovered reverse transc
 riptase activity which requires structural transformation of the polymerase
  domain to accommodate a wider DNA/RNA template. Finally\, the potential of
  Polq as a cancer drug target and ongoing Polq drug development studies wil
 l be discussed.
DTEND:20211022T200000Z
DTSTAMP:20260411T050754Z
DTSTART:20211022T190000Z
LOCATION:
SEQUENCE:0
SUMMARY:Molecular and Computational Biology Seminar - Dr. Richard Pomerantz
 \, PhD (Thomas Jefferson University)
UID:tag:localist.com\,2008:EventInstance_37759602228349
URL:https://calendar.usc.edu/event/molecular_and_computational_biology_semi
 nar_-_dr_richard_pomerantz_phd_thomas_jefferson_university
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