Molecular and Computational Biology Seminar - Dr. Richard Pomerantz, PhD (Thomas Jefferson University)

Friday, October 22 at 12:00pm to 1:00pm

This is a past event.
Virtual Event

 

 

 

Title: “Polymerase Theta: A Cancer Drug target with Reverse Transcriptase Activity”

 

Abstract: DNA polymerase theta (Polq) is a validated anti-cancer drug target that is synthetic lethal with homologous recombination (HR) factors and other DNA repair proteins, and confers cellular resistance to various genotoxic cancer therapies. POLQ is a unique gene in higher eukaryotic cells since it is the only known helicase-polymerase fusion protein. Mechanisms of Polq polymerase and helicase activities in DNA repair will be discussed, as well as it’s newly discovered reverse transcriptase activity which requires structural transformation of the polymerase domain to accommodate a wider DNA/RNA template. Finally, the potential of Polq as a cancer drug target and ongoing Polq drug development studies will be discussed.

 

 

Dial-In Information

Join Zoom Meeting

https://usc.zoom.us/j/92328890687?pwd=Nk5EVXFiZjV3MWJaKytHRmE0ZFIvZz09

Meeting ID: 923 2889 0687

Passcode: 634448

Event Type

Lecture / Talk / Workshop

Audience

Students, Alumni, Faculty/Staff

Campus

University Park Campus

Cost

FREE

Department
Molecular and Computational Biology (MCB)
Add this to your calendar

Recent Activity