This presentation will 1) Describe a theoretical framework for understanding the relationship between mindfulness and mentalization (self-other understanding) 2) Explain how this framework underpins mentalizing imagery therapy (MIT); 3) Discuss acceptability of MIT for both English language (Latino and non-Latino) caregivers and Spanish language Latino caregivers; 4) Report clinical and neuroimaging evidence for the effects of MIT on (a) reducing depressive symptoms and stress and (b) improving mentalization and mindfulness in family caregivers; 5) Compare delivery modes of MIT via in-person, virtual and smartphone application approaches.