“Germline Genetic Variation Affects the Tumor Immune Microenvironment and Immunotherapy Outcomes”

Dr. Elad Ziv, University of California San Francisco

Dr. Ziv is a Professor of Medicine at the University of California San Francisco (UCSF) and Member of the UCSF Helen Diller Family Comprehensive Cancer Center. His research is focused on the genetics of cancer susceptibility and hematological traits. In his talk, Dr. Ziv will discuss what is known about genetic variation underlying response to immune checkpoint inhibitors (ICIs) and immune related adverse events (irAEs) in cancer patients, including recent work on the germline influence on the tumor immune microenvironment and associations between polygenic risk scores for autoimmune syndromes as predictors of irAEs. He will discuss the prospect of utilizing germline genetic information in the setting of ICI therapy.