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ZNI Seminar Series : "Blood-Derived Exosomes in the Prediction and Pathogenicity of Alzheimer's Disease"
Tuesday, June 27, 2017 3pm to 4pm
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1501 San Pablo, Los Angeles, CA 90033
Biomarkers of Alzheimer’s disease (AD) can dramatically affect clinical trial design and analysis. Although imaging and CSF methods have greatly increased the ability to detect AD changes pre-mortem, these methods are expensive and invasive.
Research focusing on peripheral biomarkers as indicative of changes in the CNS is needed but work using native blood has yielded conflicting results. An important source of biomarkers in blood to consider are exosomes microvesicles released from neurons (NDEs). Understanding how NDEs traffic from CNS to CSF and blood is central for clarifying the pathogenic significance of AD proteins contained in exosomes and for validating the use of exosomes as biomarkers of AD.
In this study we demonstrate that the protein content profile of NDE can accurately differentiate AD from control patients and accurately predict conversion of MCI to AD. In animal models, intrahippocampal injection of NDE from MCI and MCI-AD converters induced tau pathology in naıve mice.
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